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Transgender and gender non-conforming activists, such as Kate Bornstein , have asserted that RLE is psychologically harmful and is a form of "gatekeeping", effectively barring individuals from transitioning for as long as possible, if not permanently. Nonsteroidal antiandrogens NSAAs used in HRT for transgender women include flutamide , nilutamide , and bicalutamide , all three of which are primarily used in the treatment of prostate cancer in cisgender men. Lower leg hair becomes less dense. Usually starts in months Breasts reach full size in years Size varies. Some people have a skin reaction to the adhesive in the patch. Testosterone has a direct role in bone health maintenance, but the steroid is also aromatized peripherally to estradiol, which has a very important role as well Symptoms of pulmonary embolism include chest pain , shortness of breath , fainting , and heart palpitations , sometimes without leg pain or swelling. After that period, dosages can be reduced.
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